OBJECTIVES OF THE REPORT

The new Yole report presents microfluidics market data for 2006-2008 and market forecasts for 2009-2014 for life sciences and in-vitro-diagnostic applications, and provides detailed analysis of the market.

A specific section is dedicated on the analysis of what happened over the last 3 years (including Alliances & mergers, new products, fund raising…), which are key elements to understand the actual and future microfluidic market.  

MICROFLUIDIC APPLICATIONS

The report describes in detail the following applications: Point of care diagnostics; Pharmaceutical and life science research; Analytical devices; Industrial & environmental testing; Drug delivery; and, clinical & veterinary diagnostics. This analysis includes the market data, trends and drivers, key players and technologies  

MICROFLUIDIC TECHNOLOGIES

The report provides an overview of the main fluid motion and manufacturing technologies. We describe, by application, the main material used (glass, polymer, silicon...), with their advantages and drawbacks.  

MICROFLUIDIC SUPPLY CHAIN

The report describes the microfluidic supply chain, from R&D to commercialization and distribution. It shows for each type of material the main players and their role in the supply chain.

MICROFLUIDIC VALUE CHAIN

The analysis of the value chain provides an understanding of costs related to the different manufacturing steps (included packaging and quality control) in relation to the cost of the final product which includes reagent, commercialization and distribution costs.

MARKET

Microfluidic components are diverse and find many applications in the diagnostic and life Sciences fields. Microfluidics has entered the Life Sciences market as a key technology to provide solution to the market requirements in terms of:

• Analysis automation through:

            - high parallelisation

            - multiplex analysis

• Reduced analysis cost by lowering sample volume and reagents used
  
• Faster analysis
  
• Higher accuracy in fluid dispensing.

In 2014, the market of microfluidic devices will exceed $3 billion. Drug discovery remains the first microfluidics market, and will continue to grow significantly as well. This is particularly true for the technologies enabling multiplexing. However, the largest growth is expected in the field of Point of Care diagnostics.

Today, some products are moving from research applications to the clinical diagnostics and point of care fields. However, this trend is limited due to the relative high manufacturing costs of many microfluidic devices and the fact that significant hurdles remain in the technology itself and its fusion into the healthcare system.

COMPANIES CITED IN THE REPORT  

Abaxis, Abbott / I stat, ACEA Bioscience, ADVALYTIX, Advanced Liquid logic, Advion Biosciences, Agilent, Applied Biophysics, Bellbrooks Laboratories, Biodot, BioFluidix, Bionas , Biosite , Boehringer Ingelgheim MicroParts, CALIPER Life Sciences, Capilix, CEA Leti, Cellectricon, Cellix, Cepheid , ChipRx Inc., Clondiag, Combimatrix, Cytoo, DALSA Semiconducteur, Debiotech , Directif GmbH, Dolomite Microfluidics, Eksigent, Epigem, Evotec , Fluidigm, Fluxion Bioscience, Genesystems / Pall Life Science, GeSim , Gyros, LabCyte , Medspray, Medtronic , Merlin Diagnostik, MicroCHIPS, MicroDrop , Nanion Technologies GmbH, Nanopoint, Nanostream, Perkin Elmer , Philips, Qiagen, Raindance Technologies, Scienion , Shimazu Biotech, Siemens Medical Solutions , SpinX Technologies, STmicroelectronics, Weidmann Plastics, Wilden, and many other…

Main benefits:

- The new Yole report presents microfluidics market forecast (2009 to 2014) for Life Sciences applications describing each market segment by higlighting key success factors, main competitors and technological trends.

- Analysis of microfluidics technologies compatibility with market segment value chain since it is key to success in the field.

1 – Executive Summary

2 - Introduction

Introduction

Methodology

3-Microfluidic markets 2009-2014

Microfluidic markets

Markets considered in this report

Market  geographical distribution

Market distribution

Impact of microfluidics

Microfluidic applications

Microfluidic components market value and forecast - Data

Microfluidic components market value and forecast – Market in M$

Microfluidic components market value and forecast – Market in Munits

Compound Annual Growth Rates 2006-2008 and 2009-2014

Market analysis

 4- What Happened since 2007

Microfluidics, a structured market

Market data versus EMMA2007 forecasts

Total diagnostics & Drug Delivery Markets 2006-2008; in M$

Microfluidic Devices Market Evolution 2006-2008, in M$

Market Breakdown in 2008

Materials by Application

Some product introduction

Investments in microfluidics since 2007

M&A in microfluidics since 2007

Life & Death

 5- Microfluidic Applications

Microfluidics Applications

Microfluidic Applications description

Microfluidics for Analytical devices

Microfluidics for Analytical devices

Agilent Technologies (US) - HPLC-Chip/MS

Eksigent Technologies (US) - nanoLC™ HPLC systems

Nanostream (US) : Veloce Micro Parallel Liquid Chromatography (µPLC) System

Advion Biosciences (US) - NanoMate System for MS sample electrospray

Cartridges for clinical and veterinary diagnostics 

Cartridges for clinical and veterinary diagnostics

MicroParts/ Merlin Diagnostik Lilliput chip

Directif GmbH – November AG Lab on a Chip

Abaxis - Piccolo® Xpress

Microfluidic devices for Pharmaceutical and life science applications

Microfluidic devices for Pharmaceutical and life science applications

Gyros Gyrolab Bioaffy™ CD

Fluidigm Dynamic Array for Single Cell Gene Expression

CEA Leti Smartdrop

Miniaturized cell based assays

Cell based assays

Miniaturized cell based assays Applications

Ion channel drug discovery and screening

Patch-clamp

Cell transfection

Living or fixed cells

Primary cells and stem cells

Drug discovery programs

Toxicology and initial ADME studies

Shear flow analysis

ACEA Bioscience’s real-time cell assay technology

ADVALYTIX – AmpliGrid™ Platform

Advanced Liquid logic

Applied Biophysics

Bellbrooks Laboratories

Bionas – Adcon plate & reader

Cellectricon

Cellix

Cytoo

Evotec – High Throughput Screening

Fluxion Bioscience: BioFlux

Nanion Technologies GmbH

Nanopoint

Raindance Technologies

SpinX Technologies (CH) - gCards™ and SpinX Lab™ for HTS

Microfluidic devices for Point of Care

Microfluidic devices for Point of Care

Abbott / I stat
Biosite POC system

STmicroelectronics:In-Check platform

Clondiag Chip Technology AssayProcessor

POC ongoing developments: Siemens Medical Solutions

POC ongoing developments: Philips Magnetic Biosensor

POC ongoing developments: DALSA Semiconducteur BioMEMS

Capillary Electrophoresis chips

Capillary Electrophoresis chips

CALIPER Life Sciences (US)

Shimazu Biotech
Qiagen  Qiaxcel

Capilix Capella platform

Microfluidic devices for Industrial and environmental testing

Microfluidic devices for Industrial and environmental testing

Cepheid - GeneXpert™ Systems

Genesystems (Pall Life Sciences)

Microdispensers

Microdispensing

Microfluidics positioning in the Liquid Handling market

Microdispensers and workflow platforms

Overview of low liquid-handling systems

LabCyte Echo 550 Liquid handler

Biodot

BioFluidix TopSpot 5

GeSim Nano-Plotters

Perkin Elmer PiezoArray

MicroDrop microdosing System

Scienion FlexArrayer

Agilent - Ink Jet SurePrint technology

Shimatzu Biotech: Chemical Inkject Printer CHIP 1000

Microfluidic devices for drug delivery

Microfluidic devices for drug delivery

Boehringer MicroParts Respimat®

Medspray: spray nozzles

Micro Infusion pumps

Medtronic Minimed Inc.

Debiotech NanopumpTM

MicroCHIPS

ChipRx Inc.

Active needle-free transdermal systems

Transdermal Microneedle developments

 6- Microfluidic Technologies

Microfluidics technologies Overview

Microfluidic Fluid motion strategy

Microfluidic Prototyping and Production

Materials by Application

Silicon as a substrate for Life Science applications

Glass as a substrate for Life Science applications

Polymers as a substrate for Life Science applications

Microfluidic technologies and materials Synthesis

Microfluidic technologies: Main trends and conclusion

Functions integration

Functions integration, a main challenge

Functions needed for Life Science applications

A multi-disciplinary challenge

Material combination, a main challenge

Packaging techniques and their evolution

Packaging evolution

Advanced packaging: The challenges

From 2D to 3D…

Packaging for Life Science applications

DALSA Semiconducteur: Capillary Electrophoresis  (CE) and DNA Separation

 7- Microfluidic supply chain

Introduction

Competences required along the microfluidic industrial chain

Expectations of the microfluidic customers

Glass industrial supply chain

Polymer industrial supply chain

Silicon Industrial supply chain

IVD Industrial supply chain

 8- Microfluidic Value chain

Value chain analysis

Case Study: Microarray component value chain

Case Study: CALIPER Life Sciences LabChip

Case Study: Cost Analysis Caliper Labchip

Case Study: Caliper Labchip; Material Variation

Case Study: Caliper Labchip; Production location

Conclusion on the value chain

 9- Conclusion

 APPENDIX

APPENDIX 1

Manufacturing Technologies

Microfluidic technologies

Chemical etching

Photo-etching of glass
Sand blasting/Powder blasting

Electro Discharge Machining (EDM)

Mechanical micromachining
Laser Micromachining

Micromolding – Injection molding
Soft Lithography

Hot Embossing

Polymer chip manufacturing techniques

Polymer microfluidic components

Polymer microtechnologies flowchart

Polymer microcomponents technology

APPENDIX 2
Yole Développement Presentation