Disposable image sensors: a revolution for microscopy and next-generation sequencing.
- Historical perspective and synergies with other markets
- Market data and forecasts at system, camera, and image sensor level, by segment (optical microscopy, transmission electron microscopy (TEM), point-ofcare microscopy, NGS) and technology(CCD, CMOS, sCMOS, TDI), in value (US$) and volume (units)
- Technology penetration and market trends, per segment
- Supply chain analysis with market share, at system level and camera level
- Technology landscape, evolutions, and roadmaps
- Provide an overview of the microscopy and NGS market at system, camera, and image sensor level, along with an understanding of established and upcoming players, their technologies (and the advantages/drawbacks), and how these will evolve in the coming years
- Present market data and forecasts at system, camera, and image sensor level, by segment (optical microscopy, transmission electron microscopy, point-of-care microscopy, and NGS), in value ($) and volume (units)
- Identify where the opportunities lie for different players along the supply chain, from materials suppliers and foundries to camera manufacturers and system developers
- Discuss the different technologies used today (CCD, CMOS, sCMOS, TDI), as well as technological trends like artificial intelligence
Table of Content
Table of contents 4
Report objectives 5
Report scope 6
Report methodology 7
About the authors 8
Companies cited in this report 9
Yole Group’s related reports 10
Executive summary 11
- Report scope
- Microscopy: historical perspective
- Next generation sequencing (NGS): context
- Market segmentation
Market forecasts 65
- Segment descriptions
- Market data and forecasts 2018 – 2024 (value, units) at system level, by segment
- Market data and forecasts 2018 – 2024 (value, units) at camera level, by segment and technology
- Market data and forecasts 2018 – 2024 (value, units) at image sensor level, by segment and technology
- Cameras and image sensors – average selling price evolution
Market trends 90
- Cameras for optical microscopy – market trends
- Cameras for electron microscopy – market trends
- Point-of-care microscopy – market trends
- High-end cameras in life sciences – market trends
- Per segment
- Technology and economic requirements, per application
- Market drivers
- Roadmaps, per segment
Supply chain and market share 145
- Ecosystem analysis
- Market share, at system and camera level
- M&A, collaborations, fundraising
- Supply chain analysis
- Business models
Technology trends 173
- Technology description: cameras and image sensors
- Available commercial products and future product launches
- AI in microscopy
Company profiles 213
Yole Développement presentation 246
MOVING TOWARD DISPOSABLE IMAGE SENSORS FOR NEXT-GENERATION SEQUENCING AND POINT-OF-CARE MICROSCOPY
Why did we choose to discuss the technology evolutions in the microscopy and next-generation sequencing (NGS) market? Because this market is undergoing enormous technological changes that are opening new market opportunities for the camera image sensors industry.
Cameras are key elements in the microscopy and NGS space. Indeed, today most microscopes are digital microscopes that use at least one (and sometimes more) cameras. The main trend in optical microscopy is to attain higher resolution, as well as faster acquisition and higher sensitivity for quicker and better diagnostics, and realtime imaging of living organisms. CCD is the main image sensor technology used today, but sCMOS is gaining market share due to an increasing need for high-speed image acquisition. However, this trend towards better imaging is counterbalanced by another trend – one that leans towards portability and use of microscopy at the point of care. These systems are sleeker and cheaper, and deliver microscopy results directly to the caregiver.
This is also the case for NGS. Two very different trends are discernable: one towards higher throughput with very expensive, bulky equipment; and another that is lower throughput, with cheaper equipment offering lower footprint and wide availability. Take for example Illumina, the optical NGS market leader with more than 80% market share: Illumina has a diverse product portfolio of very high-end systems, but recently launched a more affordable, lower-throughput system – the iSeq100. This follows the trend towards commoditization of NGS. The iSeq100 does not integrate optical systems in the instrument anymore, but uses a disposable image sensor directly inside the flow cell, which is a game-changer in the NGS market! Indeed, this makes the instrument much more affordable, enabling Illumina to place more systems and therefore sell more consumables, which they can make cheaper because of increased volumes. This trend is also seen with BGI, Illumina’s Chinese competitor, which recently announced a benchtop NGS system based on CMOS chips.
A broader trend is artificial intelligence (AI), which is upending the microscopy hardware ecosystem because deep learning could enable not only ultra-high resolution at lower hardware cost, but also automation.
This report describes the technology evolutions in the microscopy and NGS field, and the effect these developments will have on the market and ecosystem.
THOUGH EACH MARKET SEGMENT HAS DIFFERENT DYNAMICS, THE OVERALL IMAGE SENSOR MARKET FOR MICROSCOPY AND NGS WILL SHOW IMPRESSIVE GROWTH, WITH A CAGR2018-2024 OF 18% (IN VOLUME)
At system level, the global microscopy and NGS market represented $4.1B in 2018. The biggest market segment was optical microscopy ($2.5B in 2018). Cameras for microscopy and NGS represented $367M, and is expected to reach $446M in 2024 at a CAGR of 3.3%. Meanwhile, image sensors for microscopy and NGS achieved $31M in 2018. This rather small market should enjoy rapid growth (CAGR2018-2024 in value: 9%, and in volume: 18%), an improvement driven mostly by the arrival of image sensors-on-consumables in NGS. The image sensor market for microscopy is divided into four different categories, each having a different maturity level. For example, optical and transmission electron microscopy is a mature market with a low CAGR. Point-of-care microscopy was a very small, emerging market in 2018, but is poised for fast growth. Image sensors embedded in cameras for high-end NGS systems is a declining market due to the trend toward cheaper systems with less cameras.
The image sensors market for NGS consumables is booming. This new business model implies the creation of products where the image sensor is disposable, equating to a very low average selling price (compared to the image sensors previously used in microscopy and NGS systems) and very high volume.
This report describes the 2018 market and offers forecasts for the period 2018 – 2024 at system, camera, and image sensor level. The hypothesis behind these forecasts and the roadmaps leading to these assumptions are also described.
A STRUCTURED ECOSYSTEM WITH COLLABORATIONS AT DIFFERENT LEVELS OF THE SUPPLY CHAIN BETWEEN IMAGE SENSOR, CAMERA, AND SYSTEM-LEVEL PLAYERS
The $1,000 genome barrier was broken about five years ago, and we are now heading towards the $100 genome thanks to higher throughput and faster equipment. The ultimate goal is to reach as low as $10 per genome, and semiconductor technologies are key enablers for NGS affordability. The race towards sequencing inexpensiveness and commoditization is a tremendous opportunity for the semiconductor industry, because volumes will explode.
Specific to ecosystem, microscopy and NGS is a structured market with a few key players. At system level, the major players in optical microscopy are Olympus, Nikon, Zeiss, and Leica Microsystems. Combined, they hold more than 80% of optical microscopy market share. The transmission electron microscopy (TEM) main players are Jeol, Thermo Fisher Scientific, and Hitachi High-Technologies, and the optical NGS main players are Illumina, Pacific Biosciences, and BGI. At camera level, the market is also well structured, with integrated players like Olympus and Zeiss, and specialized camera players such as Teledyne, Sony, Hamamatsu, and Andor. In the TEM market the main camera players are Gatan and Thermo Fisher, which is integrated. The key image sensor providers for microscopy and NGS are Sony, ON Semiconductor, Hamamatsu, Gpixel, Omnivision, and ams.
Recent mergers and acquisitions of microscope manufacturers are aimed at finding expertise in the field of data management and software (ex: Zeiss acquiring gom in 2019; Olympus acquiring Image Stream Medical in 2017). This trends follows the parallel development of deep learning algorithms in this field.
In this report, Yole Développement’s analysts identify the key players leading the market, analyze the supply chain, and discuss the technology’s evolution and its influence on ecosystem changes.
Accu-scope, Agilent Technologies, ams, Amscope, amt, Andor, Anvajo, Artray, Aven, Basler, Baumer, Bentham, BGI, Bio-Rad, Bruker, CEA, Cellmic, Centrillion Technologies, Cnoptec, Cygnus, Dagemti, Danaher, Depixus, Dino-lite, Direct Electron, Direct Genomics, Emsis, Episenses, Euromex, Fein Optic, Fimm, Flir, Gatan, Genapsys, Genia, Gpixel, Greateyes, Hamamatsu, Hirox, Hitachi High-Technologies, Horiba, icfo, Illumina, Imec, imt, InSilixa, Intellectual Ventures, Invenios, InView, Jenoptik, Jeol, Kappa, Keyence, Kramer Scientific, Labomed, Labsmith, Lasergen, Leica Microsystems, Lissview, Matrix Vision, Meiji Techno, Micralyne, Micronit, MicroscopeIT, Midiagnostics, Mitutoyo, Motic, Nabsys, Nanotronics, Nikon, Novel Optics, Nowdiagnostics, Olympus, Omano, Omax Microscope, Omnivision, ON Semiconductor, Optika, Oxford Nanopore, Pacific Biosciences, Park Systems, pax-it, PCO, Phenomic.ai, Phograin, Photon Focus, Photonis, Photron, Pixelink, Powerchip, Qiagen, QuantuMDx, Raptor, Rigaku, Roswell Biotechnologies, SeqLL, Sight,Silex Microsystems, Sony, Spot Imaging, Stanford Computer Optics, Sunny Optical Technology, Swift, Teledyne, Thermo Fisher, Thorlabs, TSMC, TVIPS, Witec, Ximea, Zarbeco, Zeiss, and many more…