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Flow Chemistry Technologies
Mar.2012

technical criteria
5 990 €

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Description

YOLE Flow Chem. 2012Microtechnologies for chemical process intensification.

OBJECTIVES OF THE REPORT

The market of MicroReaction Technologies (MRT) dedicated to flow chemistry sharply increased over the last five years. Recent and growing involvement of the fine chemical and pharmaceutical industry clearly signals the transformation of this technology from academic settings towards applied research and production. How have micro-technologies impacted the pharmaceutical and the fine chemicals industries?

Looking back on the last 5 years with an analysis of the most relevant changes is essential to understand the market dynamics observed today. 

This report provides a comprehensive view on the flow chemistry market, including: 

  • Consolidated MRT market data (2005-2011)
  • Market forecasts (2012-2017) for modules, systems and production units.
  • Main trends and challenges
  • Modules, systems and production units supply chain.
  • The main business models
RD System Market Data
HIGHLY SEGMENTED MARKET DEPENDING ON THE ADDED VALUE OF MRT


Large chemical and pharmaceutical companies are increasingly considering MRT as a process intensification solution to solve some of their current processing problems for lab research and to debottleneck production. Nevertheless, the motivations for implementation are multiple and vary form one case to another. On the technical side, user requirements will be different if the principal goal is to precisely control the reaction kinetics, avoid hazardous situations or develop new syntheses. Likewise, drivers differ depending on the molecule life cycle.

This leads to a market segmentation of the Flow Chemistry market. For each segment the following elements are described: applications, technical and economic requirements, key technology suppliers and some examples of technologies and users.
The ability to understand to which segment a prospect belongs is essential as it determines the most appropriate offer and commercial approach.

Technical criteria
STRONG EVOLUTION FROM MRT MODULES TO INTEGRATED SYSTEMS

New players entered the field recently and previous ones have broadened their product portfolio. Therefore,  the range of MRT products available on the market became wider in terms of both performance and price.
Some systems have evolved dramatically towards the high end market, with more and more functionalities.  Meanwhile low cost systems have been introduced recently to respond to research and educational needs.
These significant changes show that the Flow Chemistry market is structuring with different strategic positioning occupied by MRT supplier.

Market shares

MRT SUPPLY CHAIN

The report describes the MRT supply chain, from R&D to commercialization and distribution. It also shows several collaboration examples between key players of the field and their market share.


MRT VALUE CHAIN

Analysis of the value chain provides an understanding of the price evolution from microreaction components sold as stand-alone modules to a complete systems installed in Production. MRT modules represent only approximately 20% of the total system cost, while the instrumentation price share can exceed 60%. 
This explains how leading companies improved their market positioning and increased their revenue by extending their offer from modules to complete systems. Moreover, it explains as well why numbering-up modules can become very expensive.

Business case analysis of MRT used for production shows that Flow Chemistry hardware is more expensive than batch chemistry (CAPEX is higher). Nevertheless, MRT appear to be cost effective solution for the exploitation by decreasing the operational costs (strong decrease of OPEX).

Table of contents

Executive Summary 4
Introduction 31
What happened since 2007? 6
> Business News
> Learning curve and S-curve
> Market in Asia
> Involvement of Pharmaceutical companies
> Continuous reactors scaling
> MRT suppliers (news players, news activities, geographical distribution) and portfolio evolutions

MicroReaction Technologies Market 2011-2017 54

> Individual modules market data
> R&D system market data
> Production system market data

Market segmentation 83

> MRT Technologies for research applications
> MRT Technologies for process development
> MRT Technologies for production applications
Industrial Status of Development 115
> MRT equipment design
> MRT materials

Advantages & challenges for MRT 124

> SWOT analysis
> Business Cases for different production applications

Focus on Pharmaceutical industry 135

> A changing environment
> MRT technologies in drug discovery

Industry organization & Trends 142

> Green Chemistry
> Supply chain
> Value chain
> Strategic maps
> Case study: R&D system cost breakdown

Summary and Conclusion 158


Companies cited

Accendo
Aetdev
Alfa Laval
Atotech
Cetoni
Chemtrix
Corning
Dai Nippon Screen
DSM
Ehrfeld Mikrotechnik BTS
ESK Ceramics


Future Chemistry
Heatric
IMM
Institute for Microchemical Technology IMT
LioniX
Little Things Factory
Lonza
Merck
Microinnova
Micronit

Mikroglas Chemtech GmbH
Modular Block
Siemens
Sigma-Aldrich
Spec Corporation
Syntics
Syrris
ThalesNano
ThinXXS
Velocys
YMC

 

KEY FEATURES OF THE REPORT

  • Analysis of the last 5 years market evolution and key events
  • 2011-2017 modules and systems forecasts from a foundry or a system provider perspective.
  • Market segmentation with key success factors by segment in order to succeed in MRT market.
  • Business cases: comparison of investment and operational costs between flow chemistry and traditional methods for different applications at a production level.
  • Strategic maps: representation of several MRT suppliers’ products portfolio according to two main criterions: the price and the performance for each product.
  • Production scale-up: comparison between numbering-up and sizing-up strategies